495 Antimicrobial peptides in atopic skin using tape stripping technique
نویسندگان
چکیده
منابع مشابه
Endogenous antimicrobial peptides and skin infections in atopic dermatitis.
BACKGROUND The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and...
متن کاملAtopic Dermatitis Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
after the injection. Results. The 5 children who used EpiPen Jr had a mean age of 5.4 years, mean weight of 18.0 kg, and achieved a maximum plasma epinephrine concentration of 2037 pg/mL at 16 minutes. Those who used EpiPen had a mean age of 6.6 years, mean weight of 25.4 kg, and had maximum plasma epinephrine concentrations of 2289 pg/mL at 15 minutes. Mean systolic blood pressure 30 minutes a...
متن کاملThe tape-stripping technique as a method for drug quantification in skin.
Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques. Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. T...
متن کاملStratum Corneum Tape Stripping: Monitoring of Inflammatory Mediators in Atopic Dermatitis Patients Using Topical Therapy.
OBJECTIVE The aim of this study was to explore the tape strip sampling technique in the assessment of stratum corneum levels of inflammatory mediators in a clinical trial setting. METHODS Thirty-eight inflammatory mediators were analyzed by a multiplex-assay in the stratum corneum, collected by adhesive tapes before and after 6 weeks of therapy, in mild and moderate atopic dermatitis (AD) pat...
متن کاملInterpretation of the human skin biotribological behaviour after tape stripping.
The present study deals with the modification of the human skin biotribological behaviour after tape stripping. The tape-stripping procedure consists in the sequential application and removal of adhesive tapes on the skin surface in order to remove stratum corneum (SC) layers, which electrically charges the skin surface. The skin electric charges generated by tape stripping highly change the sk...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.07.691